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KMID : 0370219740180040249
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Yakhak Hoeji
1974 Volume.18 No. 4 p.249 ~ p.254
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Studies on the Synthesis and Antimicrobial Activity of 2-Aryl-3-(5-nitro-2-furyl) acrylamides
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박정섭/Park JS
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Abstract
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Eighteen 2-aryl-3-(5-nitro-2-furyl) acrylamides were synthesized as antimicrobial agent, by the condensation of 2-(p-substituted phenyl)-3-(5-nitro-2-furyl) acryloyl chloride with amino component, such as sulfisoxazole, sulfamethoxypyridazine and sulfadimethoxine. All compounds showed fair bacteriostatic activity against Staphylococcus aureus 6538p, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae. 2-(p-Hydroxyphenyl)- and 2-(p-acetoxyphenyl) compounds also showed antimicrobial activity against Saccharomyces cerevisiae 396 and Aspergillus oryzae.
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